RYTARY THE KNEW "GOLD STANDARD" IN PARKINSON'S DISEASE TREATMENT
                                                                   BY SAM MOORE


A knew "Gold Standard" in PD treatment is now on the scene and is proving itself.  It is called Rytary, Ry-tar'-y..  I have just started using it so don't have any personal experience yet..  Without the price tag, it would quickly take over the  number one place in PD treatment.  The predecessor,  Sinemet  would  soon be history.
With my engineering background, I need an understandable, development history of any product I endorse.   Without the actual history,  I am compelled to invent my own.   Fortunately, I have a tool that gives  me under the skin insight into the interaction of medications with different absorption characteristics..   The tool is a medication profile plotter.   By entering the dosages and dose schedule of a day's medication protocol, I receive a plot of the days' medication blood concentration.  With this information,  I can reconstruct the thought processes and hard work that went into the development of Rytary.
Rytary is a progression of Extended Release, ER, and Control Release, CR,  Sinemet.  The advantage of ER/CR Sinemet is added therapeutic time.  A plot of the blood concentration, following doses of ER/CR Sinemet, is shown in figure one.

The advantages of this  configuration over IR Sinemet is obvious.  The disadvantage is the absorption time,  it takes too  long for the initial dose to take effect. I remember reading somewhere that Rytary uses a combination of IR and two versions of ER/CR. The developer of Rytary must have taken considerable time and research to come up with the combination of Sinemet versions  they settled on.   The  combination I arrived at in my analysis, 16.7% IR,  33.3% ER/CR 3 hour and 66.7% ER/CR 5 hour.
I have a friend who uses Rytary.  She takes two capsules  of 95 mg. Rytary 4 times a day.  This gives her 24 hour coverage of therapeutic medication.  This profile is shown in figure two.

Using the profile plotter, I would select  10 mgs. IR and 180 mgs. 5 hour.  The 24 hour plot is shown in  figure 3.  The addition of the 3 hour ER/CR does not appear to be of any real advantage.

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For a trial use of the plotter contact Sam Moore at sdurwoodm@gmail.com.  Thirty day trial is free, Donations are accepted.  The plotter was developed to study Sinemet, and requires EXCEL, which is not included.