THE AMERICAN WORKER AND THE CAUSE OF THEIR PROBLEM

I have been seeking a revelation to explain the plight of the American worker. The answer is unexpected.  It is an old problem and surprisingly began with one of America's favorite sports,  high school  and human nature.   In the early days sportsman ship was taught from the beginning grades. You were taught to accept defeat and as a victor show respect to your defeated opponent.  As years went by, sportsmanship took a backseat to pride in being number one.  Soon winning was everything.  and second place was quickly forgotten.  This was the end of sportsmanship.

As you would expect, this attitude progressed as the younger  players advanced through the ranks, from high school, to college, to professional,  to national,  and so on, until the problem had permeated the entire sports world.  Today, nobody remembers the second place team or individual, twenty four hours after the winner is announced.   When I was named Salutatorian of my high school graduating class, I was treated like a celebrity, equal to the recognition given to the Valedictorian. Today, that achievement is hardly recognized.  

Being number one has become addictive.  No one is satisfied with anything less.  People will even resort to murder to achieve the number one position in any endeavor sports or otherwise.  As a result, we have dictators, Kings and other world leaders who resort to anything, legal or e legal to achieve the spot.  

Greed has become rampant.  The desire for recognition, fame, power, wealth, and all that it brings has ruined many a potential leader.  As a result, they become mean and vindictive and resort to any means to achieve their goals.  The real question is: what is the solution? As for me, "I don't have a clue".

So, let's start a dialog of finding answers.  I'm sure there is more than one answer and the solution may be one or a combination of answers.  Let's start by setting up a  dialog blog.  Who will volunteer to chair and set up the site.        

                                MORE EVIDENCE TO THE DELIMA OF THE WORKING CLASS
                                                              BY SAMUEL D. MOORE    

I watched the national college football game  on tv the other night.  I must say, it ranks at the top for excitement.  However, I noticed one incedent that strengthened my belief as to what happened to sportsmanship and ethics in the world.  The incedent probably  wasn't noticed by anyone else,  but that is the way my mind works.  It occurred  about midway through the contest.
One of the top receivers for Alabama, touchrd the incoming ball but failed to make the catch.   He immediately jumped up, making good catch signs with his arms, in an attempt to influence the official's call.  I believe most people today would ask, "What's wrong with that?".  Exactly, this is what's wrong.  The player knowingly tried to perpetuate a lie instead of accepting the truth that he failed to make the catch.  The desire to suceed overpowered his acceptance of the truth.
This attitude is epidemic in most of today's sports venuies.  The two notable exceptions are soccer and golf.   The result of this attitude is more rules and officials.  It has gotten so bad that it has interfered with the ability to complete a contest.  In football, it is almost impossible to complete a first down.  In basketball, it is almost impossible to make a shot from the field, resulting in the outcome of the game dependent on free throws and official's decisions..  In addition,  the attempts at shifting the blame for fouls  by faking a reaction has gone viral, so to speak.  The acting should have its own Golden Globe awards show.   Remember when:  The official calls a foul and the guilty player immediately raises his hand?

 Those are the sports I am familiar with.  I am not familiar enough with other sports  to comment on them.
The resulting greed and desire for success, has made its way into the political system.  At this point, it is hard to determine if the chicken or the egg was first.  This seems to be a worldwide phenomena.                                    

                         THE UNEMPLOYED OF THE  AMERICAN WORKFORCE EXPOSED
                                                                BY SAMUEL D. MOORE


I have tried to keep this blog out of politics.  I have abandoned that cause due to a posting of Dr. Phil's on Facebook.

WAKE UP AMERICA!!!!!!!

I have respected Dr. Phil until today.  I saw his comments about unemployment on the Facebook and it sent me into a rage.  His true colors are revealed.  Another major disappointment in my faith. Dr. Phil, do you really think the un- and under- employed enjoy their condition.  Face it: The greed of the overpaid CEO's of this country, who, in the interest of there power and pocketbooks, have sent their jobs overseas, in the guise of high wages.  Now to bring them back,  they must accept minimum wages. They are even asking the American workforce to accept lower minimum wages, as a cost of bringing the jobs back, while management takes a bigger share of the profit. This is what we can expect of the administration's support of the American worker?  I am 85 years old, and, if I was physically, able would still be in the workforce, employing my fellow Americans.  I am working today, toward that goal.

I do not understand the fact that the American workforce doesn't recognize this situation.  I guess the truth is, they have been told a lie so much, that they now recognize it as the truth.  All you have to do to recognize the truth of the situation is, look at the economy growth since the democrats took partial control of our government.  Think what could have been achieved if they had full control.  Instead the republicans have thrown up roadblocks to any attempt at helping the citizens of this country, in an attempt to make Obama a failure, purely for bigot reason,s.  " TO HELL WITH THE CONSTITUTION, DESTROY OBAMA".  

I realize that this will anger many people, but, I no longer care. What I am saying needs to be said. If it enlightens just one person it is worth it.  

I hope to return to my original subject in my next posting.

   

                         DYSKINESIA DOSE SUSCEPTIBILITY RANGE
                                                         BY Sam Moore

I have found that my dyskinesia has a susceptibility range.  The range starts at about 100 mgs of levodopa IR and continues at levels of levodopa higher than I have experienced.  The Figure below shows the range I have experienced.   The intensity of the dyskinesea, when it occurs is proportional to the highest level just before the elimination period starts.  At levels less than the susceptible range is a safe range. This range starts at a level where the tremors cease.

The information is patient sensitive and will not be the same for everyone.  Relating the information to blood concentration, one hundred mgs. is equivalent to approximately 18.2 mg/ml blood concentration.  For my body weight, about 5.5 liters of blood.

The blue/green line is for 150 milligrams taken three times a day.  While I was on that protocol I did not suffer with tremors or dyscinesea.  I attribute that to the level being most of the time above the upper limit of tremors. I believe this dose level is too low to be therapeutically beneficial.

The red line is for 200 mg. taken 4 times a day. This was the worst I have suffered with dykinesea, both in length and intensity.   I never want to go through that again.  The higher the peak just before the dyskinesea, the higher the intensity.

I have been looking at profiles of  Rytary.  I think I have it down pretty good.  I understand that a friend of mine is taking Rytary, Two 95 mg. tablets, 4 times a day.  I worked up a model of Rytary so I could plot a graph of the daily profile.  The result is the graph, shown below.
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From my experience, I have found that you can have a condition where you get enough levodopa to eliminate the tremors, without having enough to  be therapeutic.  If I am correct, in the protocol that my friend is on,  I believe she is at this point.  I have taken into account that she is a small woman and would not require as large a dose as a man my size.  I believe in order to have a therapeutic effect you must have enough levodopa to make you susceptible to dyskinesea.  Fortunately, with the Rytary protocol, the level of medication remains at a high enough level to prevent triggering of dyskinesea. In the plots,  I have shown the profile for the 190 mg. tablet.

I am attaching my dose profile for a comparison to the Rytary profile.  I use a protocol of sinemet, because it is cheap, that makes me take my doses every two hours.  It ends up putting me in a dyskinsea sensitive range much of my dose period.  That combined with the large fluctuations of medication level causes me to put up with dyskinesea several times every day.   It is not possible to have 24 hour coverage .  You are limited to 12 to 14 hours.   I miss doses on my schedule, because,  I sometimes am out of range of hearing of my timer, I forget to set or activate the alarm, or I accidentally turn the sound of my alarm too low to hear.

I am impressed by the Rytary profile, because you can get 24 hour coverage and it is less susceptible to Dyskinesea than my current protocol.   Except for the cost, I think Rytary is the best solution yet for a sinemet protocol.

I believe that for ease in comparing results between patients, it makes more sense to look at the profiles in terms of mg/ml, rather than in mgs.  Mgs/ml takes into account the weight of the patient with there associated blood volume.  In order to support this recommendation I have attached a graph with two profiles. One is of  two 95  mg. tablets of Rytary taken 4 times a day by a 155 lb. patient.  he other graph is of two 95 mg. tablets of Rytary taken 4 times a day by a 110 lb. patient.

As can be seen in the graphs,  the dose has a much stronger effect on the smaller patient.   This technique will narrow the gap for comparing results.
I believe that for ease in comparing results between patients, it makes more sense to look at the profiles in terms of mg/ml, rather than in ml.  This takes into account the weight of the patient with the associated blood volume.  In order to support this recommendation I have attached a graph with two profiles. One is of  two 95  mg. tablets of Rytary taken 4 times a day by a 155 lb. patient.  The other graph is of two 95 mg. tablets of Rytary taken 4 times a day by a 110 lb. patient.

As can be seen in the graphs,  the dose has a much stronger effect on the smaller patient.   This technique will narrow the gap for comparing results.

I hope you have found this article beneficial.  If so, please "Like" it on Facebook,  or comment on my blog.  Support PD research on the Michael J. Fox foundation.  Support this blog  with donations to my account  s_durwood_m@msn.com on Paypal, or contact sdurwoodm@gmail.com to send comments.  Both positive and negative comments are welcome, although positive ones are preferred. I will try to respond.